Risk Factors for Developing Metachronous Superficial Gastric Epithelial Neoplasms after Endoscopic Submucosal Dissection

• Published in: Journal of clinical medicine Vol. 13; no. 6; p. 1587
• Main Authors: Suzuki, Tsunehiro, Goda, Kenichi, Ishikawa, Manabu, Yamaguchi, Shintaro, Yoshinaga, Tomonori, Kondo, Masayuki, Kanazawa, Mimari, Kunogi, Yasuhito, Tanaka, Takanao, Kanamori, Akira, Abe, Keiichiro, Yamamiya, Akira, Sugaya, Takeshi, Tominaga, Keiichi, Yamagishi, Hidetsugu, Masuyama, Hironori, Irisawa, Atsushi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2024; MDPI
• Subjects: Abdomen; Antibiotics; Cancer; Classification; Cohort analysis; Complications and side effects; cumulative incidence; Development and progression; Dissection; early gastric cancer; endoscopic resection; Endoscopy; gastric adenoma; Gastric cancer; Gastrointestinal tumors; Infections; Lymphatic system; Medical records; metachronous cancer; Metastasis; Metronidazole; Oncology, Experimental; Pharmaceuticals; Risk factors; stomach; Stomach cancer; Surgery; Tumors; Japan; East Asia; Helicobacter pylori; cumulative incidence; intestinal metaplasia; spontaneous disappearance; endoscopic submucosal dissection; stomach; gastric adenoma; endoscopic resection; metachronous cancer; early gastric cancer
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm13061587

Although endoscopic submucosal dissection (ESD) provides a high rate of curative resection, the remaining gastric mucosa after ESD is at risk for metachronous superficial gastric epithelial neoplasms (MSGENs). It leaves room for risk factors for developing MSGENs after ESD. This study aimed to identify clinicopathological risk factors for the occurrence of MSGENs, and to evaluate the association of ( ) with the MSGENs. We conducted a retrospective cohort study including 369 patients with 382 lesions that underwent ESD for adenoma/early gastric cancer. Twenty-seven MSGENs occurred. The subjects were divided into MSGEN and not-MSGEN groups. There was a significantly higher frequency of histological intestinal metaplasia (HIM) and initial neoplasm location in the upper or middle parts (INUM) in the MSGEN group. The HIM and INUM groups had a significantly higher cumulative incidence of MSGENs. We compared 27 patients from the MSGEN group and 27 patients from the not-MSGEN group that were matched to the MSGEN group for variables including HIM and INUM. There was a significantly higher frequency of the spontaneous disappearance of in the MSGEN group. HIM, INUM, and the spontaneous disappearance of may be clinicopathological risk factors for developing MSGENs after ESD.