Expression of phosphatase regenerating liver 3 is an independent prognostic indicator for gastric cancer

• Published in: World journal of gastroenterology : WJG Vol. 15; no. 12; pp. 1499 - 1505
• Main Authors: Dai, Ni, Lu, Ai-Ping, Shou, Cheng-Chao, Li, Ji-You
• Format: Journal Article
• Language: English
• Published: United States Department of Pathology, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China%Department of Biochemistry & Molecular Biology, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China 28.03.2009; The WJG Press and Baishideng
• Subjects: Adult; Aged; Aged, 80 and over; Brief; Disease-Free Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lymph Node Excision; Male; Middle Aged; Neoplasm Proteins - genetics; Neoplasm Staging; Palliative Care; Prognosis; Protein Tyrosine Phosphatases - genetics; Recurrence; Retrospective Studies; Stomach Neoplasms - genetics; Stomach Neoplasms - mortality; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Survival Rate; TNM分期; 免疫组织化学; 磷酸酶; 肝再生; 肿瘤复发; 胃癌患者; 阴性表达; 预后指标; Phosphatase regenerating liver 3; Gastriccancer; Recurrence; Prognosis; Antibody
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.15.1499

AIM： To investigate the prognostic significance of phosphatase regenerating liver 3 （PRL-3） protein expression in gastric cancer. METHODS： PRL-3 expression in paraffin-embedded tumor specimens from 293 patients with gastric cancer was studied retrospectively by immunohistochemistry. Nonoclonal antibody specifically against PRL-3, 3B6, was obtained with hybridoma technique. RESULTS： Positive PRL-3 expression was detected in 43.3% （227 of 293） of gastric cancer cases. High expression of PRL-3 was positively correlated with tumor size, depth of invasion, vascular/lymphatic invasion, lymph node metastasis, high TNM stage and tumor recurrence. Patients with positive PRL-3 expression had a significantly lower 5-year survival rate than those with negative expression （28.3% vs 52.9%, P 〈 0.0001）. Patients who received curative surgery, and with positive PRL-3 expression had a significant shorter overall survival and disease-free disadvantage over patients with negative expression （hazard ratio of 16.7 and 16.6, respectively; P 〈 0.0001 for both）. Multivariate analysis revealed that PRL-3 expression was an independent prognostic indicator for overall and disease-free survival of gastric cancer patients, particularly for survival in TNM stage Ⅲ patients. CONCLUSION： PRL-3 expression is a new independent prognostic indicator to predict the potential of recurrence and survival in patients with gastric cancer at the time of tumor resection,