Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects

BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and seque...

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Published inMemórias do Instituto Oswaldo Cruz Vol. 113; no. 12; p. e180328
Main Authors Lima, Lyana Rodrigues Pinto, Araújo, Nathália Alves de, Guterres, Alexandro, Pilotto, José Henrique, Niel, Christian, Paula, Vanessa Salete de
Format Journal Article
LanguageEnglish
Published Brazil Instituto Oswaldo Cruz, Ministério da Saúde 03.12.2018
Fundação Oswaldo Cruz (FIOCRUZ)
Subjects
Brazil
clade
co-infection
Coinfection - virology
Female
Genes, Viral - genetics
glycoprotein B
Herpes Genitalis - complications
Herpes Genitalis - virology
Herpesvirus 2, Human - genetics
HIV
HIV Infections - complications
HIV Infections - virology
HIV-1
HSV-2
Humans
PARASITOLOGY
Phylogeny
Polymerase Chain Reaction
Short Communication
TROPICAL MEDICINE
Brazil
Brazil
co-infection
HIV
clade
glycoprotein B
HSV-2
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Abstract BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable genetic divergence (> 1%). MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and HIV/HHV-2 coinfection need to be investigated.
AbstractList BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable genetic divergence (> 1%). MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and HIV/HHV-2 coinfection need to be investigated.
BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable genetic divergence (> 1%). MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and HIV/HHV-2 coinfection need to be investigated.BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable genetic divergence (> 1%). MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and HIV/HHV-2 coinfection need to be investigated.
Author Lima, Lyana Rodrigues Pinto
Niel, Christian
Pilotto, José Henrique
Araújo, Nathália Alves de
Paula, Vanessa Salete de
Guterres, Alexandro
AuthorAffiliation 3 Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de AIDS e Imunologia Molecular, Rio de Janeiro, RJ, Brasil
1 Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Virologia Molecular, Rio de Janeiro, RJ, Brasil
4 Hospital Geral, Nova Iguaçu, RJ, Brasil
2 Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Hantaviroses e Rickettsioses, Rio de Janeiro, RJ, Brasil
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/30517210$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1093/ve/vev003
10.1371/journal.pone.0114989
10.1128/JVI.73.1.152-160.1999
10.1128/JVI.01310-07
10.1016/j.jcv.2010.04.009
10.1590/0074-02760160354
10.1111/j.1699-0463.1994.tb04882.x
10.1002/rmv.451
10.1128/JVI.01303-15
10.4269/ajtmh.13-0315
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10.1128/JVI.01959-15
10.1038/srep44084
10.1002/jmv.24061
10.1590/S0036-46652013000500004
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Issue 12
Keywords Brazil
co-infection
HIV
clade
glycoprotein B
HSV-2
Language English
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This work is licensed under a Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0
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Lima wrote this article and performed the laboratorial tests; Araújo performed the laboratorial tests; Guterres performed the phylogenetic analyse; Pilotto collected the blood samples; Niel and de Paula revised the article.
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  end-page: 1202
  article-title: Simultaneous detection of seven sexually transmitted agents in human immunodeficiency virus-infected Brazilian women by multiplex polymerase chain reaction
  publication-title: Am J Trop Med Hyg
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Snippet BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and...
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StartPage e180328
SubjectTerms Brazil
clade
co-infection
Coinfection - virology
Female
Genes, Viral - genetics
glycoprotein B
Herpes Genitalis - complications
Herpes Genitalis - virology
Herpesvirus 2, Human - genetics
HIV
HIV Infections - complications
HIV Infections - virology
HIV-1
HSV-2
Humans
PARASITOLOGY
Phylogeny
Polymerase Chain Reaction
Short Communication
TROPICAL MEDICINE
Title Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects
URI https://www.ncbi.nlm.nih.gov/pubmed/30517210
https://www.proquest.com/docview/2179232349
https://pubmed.ncbi.nlm.nih.gov/PMC6276022
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001200402&lng=en&tlng=en
https://doaj.org/article/5a2598dabfd34446ac5561ad814df8d0
Volume 113
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