Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects

• Published in: Memórias do Instituto Oswaldo Cruz Vol. 113; no. 12; p. e180328
• Main Authors: Lima, Lyana Rodrigues Pinto, Araújo, Nathália Alves de, Guterres, Alexandro, Pilotto, José Henrique, Niel, Christian, Paula, Vanessa Salete de
• Format: Journal Article
• Language: English
• Published: Brazil Instituto Oswaldo Cruz, Ministério da Saúde 03.12.2018; Fundação Oswaldo Cruz (FIOCRUZ)
• Subjects: Brazil; clade; co-infection; Coinfection - virology; Female; Genes, Viral - genetics; glycoprotein B; Herpes Genitalis - complications; Herpes Genitalis - virology; Herpesvirus 2, Human - genetics; HIV; HIV Infections - complications; HIV Infections - virology; HIV-1; HSV-2; Humans; PARASITOLOGY; Phylogeny; Polymerase Chain Reaction; Short Communication; TROPICAL MEDICINE; Brazil; Brazil; co-infection; HIV; clade; glycoprotein B; HSV-2
• ISSN: 0074-0276; 1678-8060; 1678-8060
• DOI: 10.1590/0074-02760180328

BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable genetic divergence (> 1%). MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and HIV/HHV-2 coinfection need to be investigated.