Positive frozen section margins predict local recurrence in R0-resected squamous cell carcinoma of the head and neck

Highlights • Close margins (<5 mm) on permanent analysis are associated with aggressive tumour characteristics like high-grade differentiation, hemangiosis, lymphangiosis and regional tumour disease. • Close margins, advanced tumour size, nodal disease, high-grade differentiation, lymphangiosis a...

Full description

Saved in:
Bibliographic Details
Published inOral oncology Vol. 55; pp. 17 - 23
Main Authors Ettl, Tobias, El-Gindi, Alain, Hautmann, Matthias, Gosau, Martin, Weber, Florian, Rohrmeier, Christian, Gerken, Michael, Müller, Steffen, Reichert, Torsten, Klingelhöffer, Christoph
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2016
Subjects
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - pathology
Female
Frozen section
Frozen Sections
Head and Neck Neoplasms - pathology
Head neck cancer
Hematology, Oncology and Palliative Medicine
Humans
Local recurrence
Male
Middle Aged
Neck Dissection
Neoplasm Recurrence, Local - pathology
Otolaryngology
Prognosis
Surgical margin
Survival
Head neck cancer
Surgical margin
Frozen section
Survival
Local recurrence
Online AccessGet full text

Cover

More Information
Summary:Highlights • Close margins (<5 mm) on permanent analysis are associated with aggressive tumour characteristics like high-grade differentiation, hemangiosis, lymphangiosis and regional tumour disease. • Close margins, advanced tumour size, nodal disease, high-grade differentiation, lymphangiosis and local recurrence are predictors for poor disease-specific survival. • Positive frozen section margins highly predict local recurrence in R0-resected carcinomas of the head and neck. This points to a limited accuracy of frozen section analysis guiding revisional resection.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2016.02.012