Organs at risk's tolerance and dose limits for head and neck cancer re-irradiation: A literature review

Highlights•We reviewed the clinical literature regarding head and neck cancer re-irradiation. •We focused on radiation toxicity, organs at risk tolerance and dose limit recommendations. •Data of 3766 patients from 39studies were analyzed. •Grade ≥3 pooled acute and late toxicities were 32% and 29.3%...

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Bibliographic Details
Published inOral oncology Vol. 98; pp. 35 - 47
Main Authors Dionisi, F, Fiorica, F, D'Angelo, E, Maddalo, M, Giacomelli, I, Tornari, E, Rosca, A, Vigo, F, Romanello, D, Cianchetti, M, Tommasino, F, Massaccesi, M, Orlandi, E
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.11.2019
Subjects
Carotid blowout
Head and neck cancer
Hematology, Oncology, and Palliative Medicine
Otolaryngology
Re-irradiation dose limits
Temporal lobe radionecrosis
Tolerance of organs at risk
Re-irradiation dose limits
Temporal lobe radionecrosis
Head and neck cancer
Carotid blowout
Tolerance of organs at risk
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Summary:Highlights•We reviewed the clinical literature regarding head and neck cancer re-irradiation. •We focused on radiation toxicity, organs at risk tolerance and dose limit recommendations. •Data of 3766 patients from 39studies were analyzed. •Grade ≥3 pooled acute and late toxicities were 32% and 29.3%, respectively. •Treatment toxicity is impacted by interval time, fractionation and volumes. •Dose limits were found and discussed for carotid arteries, temporal lobes, mandible.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2019.08.017