Nervous system involvement after infection with COVID-19 and other coronaviruses

• Published in: Brain, behavior, and immunity Vol. 87; pp. 18 - 22
• Main Authors: Wu, Yeshun, Xu, Xiaolin, Chen, Zijun, Duan, Jiahao, Hashimoto, Kenji, Yang, Ling, Liu, Cunming, Yang, Chun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.07.2020
• Subjects: Betacoronavirus; Consciousness Disorders - etiology; Consciousness Disorders - physiopathology; Coronavirus 229E, Human; Coronavirus Infections - complications; Coronavirus Infections - physiopathology; Coronavirus NL63, Human; Coronavirus OC43, Human; Coronaviruses infection; COVID-19; Dysgeusia - etiology; Dysgeusia - physiopathology; Encephalitis - etiology; Encephalitis - physiopathology; Encephalitis, Viral - etiology; Encephalitis, Viral - physiopathology; Guillain-Barre Syndrome - etiology; Guillain-Barre Syndrome - physiopathology; Humans; Mechanisms; Middle East Respiratory Syndrome Coronavirus; Nervous system; Nervous System Diseases - etiology; Nervous System Diseases - physiopathology; Neurotoxicity Syndromes - etiology; Neurotoxicity Syndromes - physiopathology; Neurotoxicity Syndromes - virology; Olfaction Disorders - etiology; Olfaction Disorders - physiopathology; Pandemics; Pneumonia, Viral - complications; Pneumonia, Viral - physiopathology; Polyneuropathies - etiology; Polyneuropathies - physiopathology; SARS-CoV-2; Seizures - etiology; Seizures - physiopathology; Severe Acute Respiratory Syndrome - complications; Severe Acute Respiratory Syndrome - physiopathology; Severe acute respiratory syndrome-related coronavirus; Stroke - etiology; Stroke - physiopathology; COVID-19; Nervous system; Mechanisms; Coronaviruses infection
• ISSN: 0889-1591; 1090-2139; 1090-2139
• DOI: 10.1016/j.bbi.2020.03.031

•Coronoviruses not only affect the respiratory system, but also have deleterious effects on the central nervous system.•Most neurological diseases could be caused by coronoviruses invasion.•Coronoviruses cause nerve damage via diverse pathways. Viral infections have detrimental impacts on neurological functions, and even to cause severe neurological damage. Very recently, coronaviruses (CoV), especially severe acute respiratory syndrome CoV 2 (SARS-CoV-2), exhibit neurotropic properties and may also cause neurological diseases. It is reported that CoV can be found in the brain or cerebrospinal fluid. The pathobiology of these neuroinvasive viruses is still incompletely known, and it is therefore important to explore the impact of CoV infections on the nervous system. Here, we review the research into neurological complications in CoV infections and the possible mechanisms of damage to the nervous system.