Serum Specific IgE to Thyroid Peroxidase Activates Basophils in Aspirin Intolerant Urticaria

Thyroid antibodies are frequently observed in urticaria patients, but their roles in urticaria are not clearly elucidated. We investigated the role of serum specific IgE to thyroid peroxidase (TPO) in patients with aspirin intolerant acute urticaria (AIAU) and aspirin intolerant chronic urticaria (A...

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Bibliographic Details
Published inJournal of Korean medical science Vol. 30; no. 6; pp. 705 - 709
Main Authors Shin, Yoo Seob, Suh, Dong-Hyeon, Yang, Eun-Mi, Ye, Young-Min, Park, Hae-Sim
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Academy of Medical Sciences 01.06.2015
대한의학회
Subjects
Adult
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Aspirin - adverse effects
Autoantibodies - immunology
Basophils - drug effects
Basophils - immunology
Humans
Immunoglobulin E - blood
Immunoglobulin E - immunology
Iodide Peroxidase - blood
Iodide Peroxidase - immunology
Original
Urticaria - chemically induced
Urticaria - immunology
Urticaria - pathology
의학일반
Autoimmunity
Thyroid Peroxidase Antibody
Aspirin Intolerance
Urticaria
Basophil Activation Test
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ISSN1011-8934
1598-6357
DOI10.3346/jkms.2015.30.6.705

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Summary:Thyroid antibodies are frequently observed in urticaria patients, but their roles in urticaria are not clearly elucidated. We investigated the role of serum specific IgE to thyroid peroxidase (TPO) in patients with aspirin intolerant acute urticaria (AIAU) and aspirin intolerant chronic urticaria (AICU). We recruited 59 AIAU and 96 AICU patients with 69 normal controls (NC). Serum specific IgE to TPO was measured by manual direct ELISA, and CD203c expressions on basophil with additions of TPO were measured to prove a direct role of TPO in effector cells. The prevalences of serum specific IgE to TPO were significantly higher in AIAU (15.2%) and AICU groups (7.5%) compared to NC (0%, P=0.018: P=0.013, respectively). Flow cytometry showed CD203c induction in a dose dependent manner with serial additions of TPO in some AIAU and AICU patients having high specific IgE to TPO. Our findings show that the prevalence of serum specific IgE to TPO was significantly higher in both AIAU and AICU patients than in NC. It is suggested that specific IgE to TPO play a pathogenic role in AIAU and AICU.
Bibliography:G704-000345.2015.30.6.011
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2015.30.6.705