Genome sequence of the Asian Tiger mosquito,Aedes albopictus,reveals insights into its biology, genetics, and evolution

The Asian tiger mosquito,Aedes albopictus,is a highly successful invasive species that transmits a number of human viral diseases, including dengue and Chikungunya fevers. This species has a large genome with significant population-based size variation. The complete genome sequence was determined fo...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 112; no. 44; pp. E5907 - E5915
Main Authors Chen, Xiao-Guang, Jiang, Xuanting, Gu, Jinbao, Xu, Meng, Wu, Yang, Deng, Yuhua, Zhang, Chi, Bonizzoni, Mariangela, Dermauw, Wannes, Vontas, John, Armbruster, Peter, Huang, Xin, Yang, Yulan, Zhang, Hao, He, Weiming, Peng, Hongjuan, Liu, Yongfeng, Wu, Kun, Chen, Jiahua, Lirakis, Manolis, Topalis, Pantelis, Van Leeuwen, Thomas, Hall, Andrew Brantley, Jiang, Xiaofang, Thorpe, Chevon, Mueller, Rachel Lockridge, Sun, Cheng, Waterhouse, Robert Michael, Yan, Guiyun, Tu, Zhijian Jake, Fang, Xiaodong, James, Anthony A.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 03.11.2015
National Acad Sciences
SeriesPNAS Plus
Subjects
Adaptability
Aedes - classification
Aedes - genetics
Aedes - physiology
Aedes albopictus
Animals
Aquatic insects
Biological Sciences
Dengue fever
Deoxyribonucleic acid
DNA
Evolution, Molecular
Genetics
Genome, Insect
Genomes
Insecticides
Invasive insects
Invasive species
Mosquitoes
Nonnative species
Olfaction
Phylogeny
PNAS Plus
Vector-borne diseases
Viral diseases
China
China, People's Rep
diapause
transposons
insecticide resistance
mosquito genome
flavivirus
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Summary:The Asian tiger mosquito,Aedes albopictus,is a highly successful invasive species that transmits a number of human viral diseases, including dengue and Chikungunya fevers. This species has a large genome with significant population-based size variation. The complete genome sequence was determined for the Foshan strain, an established laboratory colony derived from wild mosquitoes from southeastern China, a region within the historical range of the origin of the species. The genome comprises 1,967 Mb, the largest mosquito genome sequenced to date, and its size results principally from an abundance of repetitive DNA classes. In addition, expansions of the numbers of members in gene families involved in insecticide-resistance mechanisms, diapause, sex determination, immunity, and olfaction also contribute to the larger size. Portions of integrated flavivirus-like genomes support a shared evolutionary history of association of these viruses with their vector. The large genome repertory may contribute to the adaptability and success ofAe. albopictusas an invasive species.
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Author contributions: X.-G.C. and A.A.J. designed research; X.-G.C., Xuanting Jiang, J.G., M.X., Y.W., Y.D., C.Z., M.B., W.D., J.V., P.A., X.H., Y.Y., H.Z., W.H., H.P., Y.L., K.W., J.C., M.L., P.T., T.V.L., A.B.H., Xiaofang Jiang, C.T., R.L.M., C.S., R.M.W., G.Y., Z.J.T., X.F., and A.A.J. performed research; X.-G.C., Xuanting Jiang, and J.G. analyzed data; and X.-G.C. and A.A.J. wrote the paper.
Edited by David L. Denlinger, Ohio State University, Columbus, OH, and approved September 22, 2015 (received for review August 20, 2015)
ISSN:0027-8424
1091-6490
1091-6490
DOI:10.1073/pnas.1516410112