Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids

The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heteroge...

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Published inMemórias do Instituto Oswaldo Cruz Vol. 112; no. 8; pp. 572 - 576
Main Authors Damasceno, Jeziel D, Silva, Gabriel LA, Tschudi, Christian, Tosi, Luiz Ro
Format Journal Article
LanguageEnglish
Published Brazil Instituto Oswaldo Cruz, Ministério da Saúde 01.08.2017
Fundação Oswaldo Cruz (FIOCRUZ)
Subjects
Leishmania - genetics
Leishmania telomere
PARASITOLOGY
Repetitive Sequences, Nucleic Acid - genetics
RNA - genetics
Short Communication
Telomerase - genetics
telomere transcription
TERRA
TROPICAL MEDICINE
Trypanosoma brucei brucei - genetics
Trypanosoma brucei telomere
TERRA
telomere transcription
Trypanosoma brucei telomere
Leishmania telomere
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Abstract The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heterogeneous in size and partially polyadenylated. The levels of TERRA transcripts appear to be modulated through the life cycle in both trypanosomatids investigated, suggesting that TERRA play a stage-specific role in the life cycle of these early-branching eukaryotes.
AbstractList The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heterogeneous in size and partially polyadenylated. The levels of TERRA transcripts appear to be modulated through the life cycle in both trypanosomatids investigated, suggesting that TERRA play a stage-specific role in the life cycle of these early-branching eukaryotes.
The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp . and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heterogeneous in size and partially polyadenylated. The levels of TERRA transcripts appear to be modulated through the life cycle in both trypanosomatids investigated, suggesting that TERRA play a stage-specific role in the life cycle of these early-branching eukaryotes.
Author Tschudi, Christian
Damasceno, Jeziel D
Silva, Gabriel LA
Tosi, Luiz Ro
AuthorAffiliation 2 Yale UniversitySchool of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, USA
1 Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Ribeirão Preto, SP, Brasil
AuthorAffiliation_xml – name: 2 Yale UniversitySchool of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, USA
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  givenname: Jeziel D
  surname: Damasceno
  fullname: Damasceno, Jeziel D
  organization: Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Ribeirão Preto, SP, Brasil
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  givenname: Gabriel LA
  surname: Silva
  fullname: Silva, Gabriel LA
  organization: Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Ribeirão Preto, SP, Brasil
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  organization: Yale UniversitySchool of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, USA
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  givenname: Luiz Ro
  surname: Tosi
  fullname: Tosi, Luiz Ro
  organization: Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Ribeirão Preto, SP, Brasil
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CitedBy_id crossref_primary_10_1093_nar_gkae392
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10.1093/nar/gkl1100
10.1186/1471-2164-10-152
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10.1126/science.1112181
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Issue 8
Keywords TERRA
telomere transcription
Trypanosoma brucei telomere
Leishmania telomere
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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JDD - Conceived and performed experiments and wrote the manuscript; GLAS - performed experiments shown in Fig. 1C; CT - conceived experiments and critically revised the manuscript; LROT - conceived experiments, supervised the project and wrote the manuscript.
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Snippet The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in...
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SubjectTerms Leishmania - genetics
Leishmania telomere
PARASITOLOGY
Repetitive Sequences, Nucleic Acid - genetics
RNA - genetics
Short Communication
Telomerase - genetics
telomere transcription
TERRA
TROPICAL MEDICINE
Trypanosoma brucei brucei - genetics
Trypanosoma brucei telomere
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Title Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids
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