Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids

The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heteroge...

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Published inMemórias do Instituto Oswaldo Cruz Vol. 112; no. 8; pp. 572 - 576
Main Authors Damasceno, Jeziel D, Silva, Gabriel LA, Tschudi, Christian, Tosi, Luiz Ro
Format Journal Article
LanguageEnglish
Published Brazil Instituto Oswaldo Cruz, Ministério da Saúde 01.08.2017
Fundação Oswaldo Cruz (FIOCRUZ)
Subjects
Leishmania - genetics
Leishmania telomere
PARASITOLOGY
Repetitive Sequences, Nucleic Acid - genetics
RNA - genetics
Short Communication
Telomerase - genetics
telomere transcription
TERRA
TROPICAL MEDICINE
Trypanosoma brucei brucei - genetics
Trypanosoma brucei telomere
TERRA
telomere transcription
Trypanosoma brucei telomere
Leishmania telomere
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Summary:The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heterogeneous in size and partially polyadenylated. The levels of TERRA transcripts appear to be modulated through the life cycle in both trypanosomatids investigated, suggesting that TERRA play a stage-specific role in the life cycle of these early-branching eukaryotes.
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JDD - Conceived and performed experiments and wrote the manuscript; GLAS - performed experiments shown in Fig. 1C; CT - conceived experiments and critically revised the manuscript; LROT - conceived experiments, supervised the project and wrote the manuscript.
AUTHORS’ CONTRIBUTION
ISSN:0074-0276
1678-8060
1678-8060
0074-0276
DOI:10.1590/0074-02760170054