An elevated 1-h post- load glucose level during the oral glucose tolerance test detects prediabetes

• Published in: Diabetes & metabolic syndrome clinical research & reviews Vol. 11; no. 2; pp. 137 - 139
• Main Authors: Buysschaert, Martin, Bergman, Michael, Yanogo, Donald, Jagannathan, Ram, Buysschaert, Benoit, Preumont, Vanessa
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.04.2017
• Subjects: 1-h post-load glycemia; Adult; Aged; Cohort Studies; Diagnosis; Endocrinology & Metabolism; Female; Glucose Tolerance Test - methods; HbA1c; HOMA; Humans; Male; Middle Aged; OGTT; Postprandial Period; Prediabetes; Prediabetic State - blood; Prediabetic State - diagnosis; 1-h post-load glycemia; HOMA; Diagnosis; Prediabetes; OGTT; HbA1c; HbA 1c; HbA(1c)
• ISSN: 1871-4021; 1878-0334; 1878-0334
• DOI: 10.1016/j.dsx.2016.12.002

The objective of the study was to compare the diagnosis of dysglycemic states by conventional oral glucose tolerance test (OGTT) criteria (fasting and 2-h plasma glucose) with the 1-h post-load plasma glucose level. 34 individuals (mean age: 55±13years; BMI: 27.7±6.3kg/m2) at risk for prediabetes were administered a 75g OGTT. Individuals with normal glucose tolerance (NGT) or prediabetes were identified according to fasting and/or 2-h plasma glucose (PG) concentrations. Subsequently, subjects were divided in 2 groups: group 1 (n=21) with a 1-h PG<155mg/dl and group 2 (n=13) with a 1-h PG≥155mg/dl. HOMA was performed to assess β-cell function and insulin sensitivity. NGT or prediabetes based on conventional criteria correlated with the 1-h PG<or≥155mg/dl (p<0.001). Moreover, the 1-h PG≥155mg/dl was associated with higher HbA1c levels (6.1±0.5 vs. 5.5±0.3%, p<0.001) and significantly impaired insulin secretion and hyperbolic product (BxS) on HOMA test vs. 1-h PG<155mg/dl. The 1-h post-load plasma glucose value ≥155mg/dl is strongly associated with conventional criteria for (pre)diabetes and alterations of β-cell function.