High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant

Acinic cell carcinoma with high-grade transformation of the salivary gland is an unusual variant with less than fifty cases being reported in the literature. It is characterized by a low- and high-grade component juxtaposed with one another and tends to take on a more aggressive clinical course than...

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Published inCase reports in otolaryngology Vol. 2017; no. 2017; pp. 1 - 4
Main Authors Al Zaher, Nabil, Al Zaher, Yaseer, Alotaibi, Faiza, Al-Otaibi, Sarah S., Dababo, M. Anas
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2017
Hindawi
Hindawi Limited
Wiley
Subjects
Biopsy
Care and treatment
Case Report
Case studies
Chemotherapy
Diagnosis
Dissection
Gangrene
Lymphatic system
Medical prognosis
Metastasis
Neck dissection
Parotidectomy
Pathology
Radiation therapy
Radiotherapy
Salivary gland tumors
Surgery
Thyroid gland
Tomography
Tumors
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Summary:Acinic cell carcinoma with high-grade transformation of the salivary gland is an unusual variant with less than fifty cases being reported in the literature. It is characterized by a low- and high-grade component juxtaposed with one another and tends to take on a more aggressive clinical course than its low-grade counterpart, suggesting a poor clinical outcome. We, hereby, report a case of acinic cell carcinoma in a 48-year-old woman with a 6-month history of a right parotid facial swelling rapidly increasing in size. The tumor was initially resected; however, residual focal tissue subsequently revealed areas typical of low-grade acinic cell carcinoma as well as high-grade transformation/dedifferentiation via histopathology.
Bibliography:Academic Editor: Abrão Rapoport
ISSN:2090-6765
2090-6773
DOI:10.1155/2017/7296467