A polydimethylsiloxane-based axicon lens for focused ultrasonic brain stimulation techniques

In this work, we built ultrasonic disc-shaped transducer for targeted neuromodulation with the addition of a solid axicon lens based on a polydimethylsiloxane (PDMS) interface. We made a numerical and experimental characterization of its acoustic field. The motor cortex of CF-1 mice was stimulated,...

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Bibliographic Details
Published inAcoustical Science and Technology Vol. 40; no. 2; pp. 116 - 126
Main Authors Acquaticci, Fabin, Guarracino, Juan F., Gwirc, Sergio N., Lew, Sergio E.
Format Journal Article
LanguageEnglish
Published Tokyo ACOUSTICAL SOCIETY OF JAPAN 01.03.2019
Japan Science and Technology Agency
Subjects
Axicon lens
Brain
Focused ultrasound
Lenses
Motors
Muscles
Muscular function
Neuromodulation
Polydimethylsiloxane
Silicone resins
Spatial resolution
Transcranial stimulation
Transducers
Ultrasonic imaging
Ultrasound axicon
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Summary:In this work, we built ultrasonic disc-shaped transducer for targeted neuromodulation with the addition of a solid axicon lens based on a polydimethylsiloxane (PDMS) interface. We made a numerical and experimental characterization of its acoustic field. The motor cortex of CF-1 mice was stimulated, through the skin and skull into the intact brain, with low-intensity pulsed ultrasound. Evoked muscle responses in different body segments were clearly observed, including hindlimb, forelimb, and tail. Axicon lens affixed on the face of the transducer makes possible a targeted modulation of the motor cortex by pulsed ultrasound, inducing muscle contraction in a specific body segment. In this approach, the lateral and axial spatial resolution is comparable to spherical segment ultrasound transducers, but with a shorter focal length. Thus, ultrasound axicon looks attractive to investigate the functional contributions of fine-grained spatial structures in the brain.
ISSN:1346-3969
1347-5177
DOI:10.1250/ast.40.116