Smart nanosystems Bio-inspired technologies that interact with the host environment

Nanoparticle technologies intended for human administration must be designed to interact with, and ideally leverage, a living host environment. Here, we describe smart nanosystems classified in two categories: (i) those that sense the host environment and respond and (ii) those that first prime the...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 112; no. 47; pp. 14460 - 14466
Main Authors Kwon, Ester J., Lo, Justin H., Bhatia, Sangeeta N.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 24.11.2015
National Acad Sciences
Subjects
Biological Sciences
Diagnostics
Homeostasis
Humans
Hydrogen-Ion Concentration
Nanomedicine
Nanoparticles
Nanotechnology
Oxidation-Reduction
Physical Sciences
SPECIAL FEATURE: PERSPECTIVE
smart nanomaterials
cancer nanotechnology
host priming
nanosystems
environment-responsive
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Summary:Nanoparticle technologies intended for human administration must be designed to interact with, and ideally leverage, a living host environment. Here, we describe smart nanosystems classified in two categories: (i) those that sense the host environment and respond and (ii) those that first prime the host environment to interact with engineered nanoparticles. Smart nanosystems have the potential to produce personalized diagnostic and therapeutic schema by using the local environment to drive material behavior and ultimately improve human health.
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Author contributions: E.J.K., J.H.L., and S.N.B. wrote the paper.
Edited by Mark E. Davis, California Institute of Technology, Pasadena, CA, and approved September 18, 2015 (received for review June 1, 2015)
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1508522112