Herpes Simplex Virus Type-I and Pyogenic Granuloma: A Vascular Endothelial Growth Factor-Mediated Association

Pyogenic granuloma (PG) is a vascular endothelial growth factor (VEGF)-related neoangiogenic process. Minor trauma, chronic irritation, certain drugs and pregnancy may favor PG. Viral triggers have not been reported up to date. A 52-year-old woman with hairy-cell leukemia presented because of a 3-mo...

Full description

Saved in:
Bibliographic Details
Published inCase reports in dermatology Vol. 5; no. 2; pp. 236 - 243
Main Authors el Hayderi, L., Paurobally, D., Fassotte, M.F., André, J., Arrese, J.E., Sadzot-Delvaux, C., Ruebben, A., Nikkels, A.F.
Format Journal Article Web Resource
LanguageEnglish
Published Basel, Switzerland Karger 28.08.2013
S. Karger AG
Karger Publishers
Subjects
Angiogenesis
Dermatologie
Dermatology
Herpes simplex virus
Human health sciences
Published: August 2013
Pyogenic granuloma
Sciences de la santé humaine
Valaciclovir
Vascular endothelial growth factor
Valaciclovir
Angiogenesis
Pyogenic granuloma
Vascular endothelial growth factor
Herpes simplex virus
Online AccessGet full text

Cover

More Information
Summary:Pyogenic granuloma (PG) is a vascular endothelial growth factor (VEGF)-related neoangiogenic process. Minor trauma, chronic irritation, certain drugs and pregnancy may favor PG. Viral triggers have not been reported up to date. A 52-year-old woman with hairy-cell leukemia presented because of a 3-month history of a giant pseudotumoral lesion on her left cheek. All prior antibacterial, antifungal and anti-inflammatory treatments had failed. Histology revealed PG with sparse and isolated epithelial cell aggregates. Immunohistochemistry (IHC) identified herpes simplex virus type-I (HSV-I) antigens in the nuclei and cytoplasm of normal-appearing as well as cytopathic epithelial cells, suggesting a chronic, low-productive HSV infection. No HSV-I signal was evidenced in the endothelial cells of the PG. Furthermore, IHC revealed VEGF in the HSV-I infected epithelial cells as well as within the PG endothelial cells. These results incited oral treatment with valaciclovir, and the PG promptly resolved after 2 weeks. These findings suggest that a chronic HSV-I infection might play an indirect, partial role in neoangiogenesis, presumably via HSV-I infection-related stimulation of keratinocytic VEGF production.
Bibliography:scopus-id:2-s2.0-84884272780
ISSN:1662-6567
1662-6567
DOI:10.1159/000354570