A strategy to passively reduce neuroinflammation surrounding devices implanted chronically in brain tissue by manipulating device surface permeability

Abstract Available evidence indicates that pro-inflammatory cytokines produced by immune cells are likely responsible for the negative sequela associated with the foreign body response (FBR) to chronic indwelling implants in brain tissue. In this study a computational modeling approach was used to d...

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Bibliographic Details
Published inBiomaterials Vol. 36; pp. 33 - 43
Main Authors Skousen, John L, Bridge, Michael J, Tresco, Patrick A
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.01.2015
Subjects
Advanced Basic Science
Animals
Brain
Brain - immunology
Coating
Cytokine
Cytokines
Cytokines - immunology
Dentistry
Devices
Diffusion
Electrode
Finite Element Analysis
Foreign body response
Foreign-Body Reaction - etiology
Foreign-Body Reaction - immunology
Foreign-Body Reaction - prevention & control
Inflammation
Macrophage
Male
Medical devices
Permeability
Prostheses and Implants - adverse effects
Rats, Sprague-Dawley
Surgical implants
Foreign body response
Inflammation
Electrode
Finite element analysis
Cytokine
Macrophage
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Summary:Abstract Available evidence indicates that pro-inflammatory cytokines produced by immune cells are likely responsible for the negative sequela associated with the foreign body response (FBR) to chronic indwelling implants in brain tissue. In this study a computational modeling approach was used to design a diffusion sink placed at the device surface that would retain pro-inflammatory cytokines for sufficient time to passively antagonize their impact on the FBR. Using quantitative immunohistochemistry, we examined the FBR to such engineered devices after a 16-week implantation period in the cortex of adult male Sprague–Dawley rats. Our results indicate that thick permeable surface coatings, which served as diffusion sinks, significantly reduced the FBR compared to implants either with no coating or with a thinner coating. The results suggest that increasing surface permeability of solid implanted devices to create a diffusion sink can be used to reduce the FBR and improve biocompatibility of chronic indwelling devices in brain tissue.
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ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2014.08.039