Consumption of trans-Fatty Acid and Its Association with Colorectal Adenomas

• Published in: American journal of epidemiology Vol. 168; no. 3; pp. 289 - 297
• Main Authors: Vinikoor, Lisa C., Schroeder, Jane C., Millikan, Robert C., Satia, Jessie A., Martin, Christopher F., Ibrahim, Joseph, Galanko, Joseph A., Sandler, Robert S.
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 01.08.2008; Oxford Publishing Limited (England)
• Subjects: Adenoma - diagnosis; Adenoma - epidemiology; Adenoma - etiology; Adenoma - prevention & control; Adult; Aged; Aged, 80 and over; Analysis. Health state; Biological and medical sciences; Case-Control Studies; colonic polyps; Colonoscopy; Colorectal cancer; colorectal neoplasms; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - etiology; Colorectal Neoplasms - prevention & control; Cross-Sectional Studies; Diet; Diet Surveys; dietary fats; Epidemiology; Feeding Behavior; Female; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; Humans; Life Style; Male; Medical sciences; Middle Aged; North Carolina - epidemiology; Odds Ratio; Original Contributions; Prevalence; Public health. Hygiene; Public health. Hygiene-occupational medicine; Risk Factors; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Surveys and Questionnaires; Trans fats; trans fatty acids; Trans Fatty Acids - adverse effects; Tumors; fatty acids; dietary fats; colorectal neoplasms; colonic polyps; Human; trans fatty acids; Rectal disease; Digestive system; Gut; Colorectal cancer; Lipids; Malignant tumor; Epidemiology; Feeding; Colonic disease; Colorectal adenoma; Association; Trans fatty acid; Food intake; Digestive diseases; Intestinal disease; Benign neoplasm; Colon; Cancer; Polyp
• ISSN: 0002-9262; 1476-6256
• DOI: 10.1093/aje/kwn134

trans-Fatty acid consumption is known to have detrimental effects on cardiovascular health, but little is known about its role in digestive tract neoplasia. To investigate the association between colorectal adenomas and trans-fatty acid consumption, the authors utilized data from a cross-sectional study of 622 individuals who underwent complete colonoscopy between 2001 and 2002 at the University of North Carolina Hospitals. Participants were interviewed about demographic, lifestyle, and dietary factors thought to be related to colorectal cancer. trans-Fatty acid consumption, energy adjusted by the residual method, was categorized into quartiles based on its distribution in controls. Compared with participants in the lowest quartile of consumption, those in the highest quartile had an increased prevalence of colorectal adenomas, with an adjusted prevalence odds ratio of 1.86 (95% confidence interval: 1.04, 3.33). The authors further investigated the relation between trans-fatty acid consumption and colorectal neoplasia by examining the adenoma characteristics, with the adjusted prevalence odds ratios showing little or no difference by adenoma location, size, or number. These results suggest that consumption of high amounts of trans-fatty acid may increase the risk of colorectal neoplasia, and they provide additional support to recommendations to limit trans-fatty acid consumption.