Hepatogenic Potential of Human Bone Marrow and Umbilical Cord Blood Mesenchymal Stem Cells

• Published in: Bulletin of experimental biology and medicine Vol. 151; no. 1; pp. 142 - 149
• Main Authors: Kosmacheva, S. M., Seviaryn, I. N., Goncharova, N. V., Petyovka, N. V., Potapnev, M. P.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.05.2011; Springer; Springer Nature B.V
• Subjects: Albumin; Albumins - biosynthesis; Alkaline phosphatase; Alkaline Phosphatase - biosynthesis; Antigens, CD - biosynthesis; Biomarkers - metabolism; Biomedical and Life Sciences; Biomedicine; Bone marrow; Bone Marrow Cells - cytology; Bone Marrow Cells - metabolism; Cell Biology; Cell Differentiation - drug effects; Cells, Cultured; Cytokeratin; Cytology; Differentiation; Fetal Blood - cytology; Fetal Blood - metabolism; Flow Cytometry; Glucose metabolism; Glycogen; Glycogen - biosynthesis; Hepatocytes - cytology; Hepatocytes - metabolism; Humans; Immunophenotyping; Intercellular Signaling Peptides and Proteins - pharmacology; Internal Medicine; Keratin; Keratins - biosynthesis; Laboratory Medicine; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - drug effects; Mesenchymal Stem Cells - metabolism; Mesenchyme; mRNA; Pathology; RNA; RNA, Messenger - biosynthesis; Stem cells; Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine); Umbilical cord; hepatogenic differentiation; human umbilical cord blood; mesenchymal stem cells; differentiation markers; bone marrow
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-011-1276-1

Conditions of human BM and umbilical cord blood MSC in vitro differentiation in the hepatogenic direction were studied. Changes in cell morphology, phenotype, acquisition of the capacity to produce albumin and accumulate glycogen, express cytokeratin, alkaline phosphatase, and albumin mRNA indicated that BM and umbilical cord blood MSC differentiated in vitro into immature hepatocyte-like cells.