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A specifically engineered Zika subunit vaccine based on the viral envelope protein mediates protective immunity in mice without inducing the cross-reactive antibodies responsible for antibody-dependent enhancement of infection with dengue virus.

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Bibliographic Details
Published inNature immunology Vol. 20; no. 10; pp. 1266 - 1268
Main Authors Heinz, Franz X., Stiasny, Karin
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.10.2019
Nature Publishing Group
Subjects
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Antibodies
Antibody-Dependent Enhancement
Biomedical and Life Sciences
Biomedicine
Dengue
Dengue fever
Epigenetics
Guillain-Barre syndrome
Humans
Immunoglobulins
Immunology
Infections
Infectious Diseases
Lymphocytes
Metabolism
Mutation
News & Views
news-and-views
Proteins
Respiration
Vaccines
Vaccines, Subunit
Vector-borne diseases
Viral envelope proteins
Zika Virus
Zika Virus Infection
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Summary:A specifically engineered Zika subunit vaccine based on the viral envelope protein mediates protective immunity in mice without inducing the cross-reactive antibodies responsible for antibody-dependent enhancement of infection with dengue virus.
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SourceType-Scholarly Journals-1
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ObjectType-Commentary-3
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ISSN:1529-2908
1529-2916
DOI:10.1038/s41590-019-0497-8