Magnetoenterography for the Detection of Partial Mesenteric Ischemia

• Published in: The Journal of surgical research Vol. 239; pp. 31 - 37
• Main Authors: Somarajan, Suseela, Muszynski, Nicole D., Olson, Joseph D., Bradshaw, Leonard A., Richards, William O.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2019
• Subjects: Animals; Disease Models, Animal; Electrodes; Electrodiagnosis - instrumentation; Electrodiagnosis - methods; Electromyogram; Electrophysiological Phenomena - physiology; Female; Humans; Intestine, Small - blood supply; Intestine, Small - physiopathology; Magnetoenterogram; Magnetometry - instrumentation; Magnetometry - methods; Male; Mesenteric Artery, Superior - surgery; Mesenteric Ischemia - diagnosis; Mesenteric Ischemia - etiology; Mesenteric Ischemia - physiopathology; Slow wave; SQUID magnetometer; Swine; Electromyogram; SQUID magnetometer; Magnetoenterogram; Slow wave
• ISSN: 0022-4804; 1095-8673; 1095-8673
• DOI: 10.1016/j.jss.2019.01.034

Acute mesenteric ischemia represents a life-threatening gastrointestinal condition. A noninvasive diagnostic modality that identifies mesenteric ischemia patients early in the disease process will enable early surgical intervention. Previous studies have identified significant changes in the small-bowel electrical slow-wave parameters during intestinal ischemia caused by total occlusion of the superior mesenteric artery. The purpose of this study was to use noninvasive biomagnetic techniques to assess functional physiological changes in intestinal slow waves in response to partial mesenteric ischemia. We induced progressive intestinal ischemia in normal porcine subjects (n = 10) by slowly increasing the occlusion of the superior mesenteric artery at the following percentages of baseline flow: 50%, 75%, 90%, and 100% while simultaneous transabdominal magnetoenterogram (MENG) and serosal electromyogram (EMG) recordings were being obtained. A statistically significant serosal EMG amplitude decrease was observed at 100% occlusion compared with baseline, whereas no significant change was observed for MENG amplitude at any progressive occlusion levels. MENG recordings showed significant changes in the frequency and percentage of power distributed in bradyenteric and normoenteric frequency ranges at 50%, 75%, 90%, and 100% vessel occlusions. In serosal EMG recordings, a similar percent power distribution (PPD) effect was observed at 75%, 90%, and 100% occlusion levels. Serosal EMG showed a statistically significant increase in tachyenteric PPD at 90% and 100% occlusion. We observed significant increase in tachyenteric PPD only at the 100% occlusion level in MENG recordings. Ischemic changes in the intestinal slow wave can be detected early and noninvasively even with partial vascular occlusion. Our results suggest that noninvasive MENG may be useful for clinical diagnosis of partial mesenteric ischemia.