The use of circulating cathodic antigen rapid test and serology for diagnosis of active Schistosoma mansoni infection in migrants in Italy, a non-endemic country: a cross sectional study

Diagnosis of schistosomiasis in migrants coming from endemic areas can be difficult, especially in asymptomatic subjects. Light-intensity disease, in fact, may be missed due to the low sensitivity of the stool microscopy and serologic testing cannot distinguish between a resolved infection and an ac...

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Published inMemórias do Instituto Oswaldo Cruz Vol. 112; no. 6; pp. 452 - 455
Main Authors Infurnari, Laura, Galli, Laura, Bigoloni, Alba, Carbone, Alessia, Chiappetta, Stefania, Sala, Angelo, Ceserani, Norberto, Lazzarin, Adriano, Castagna, Antonella, Gaiera/, Giovanni
Format Journal Article
LanguageEnglish
Published Brazil Instituto Oswaldo Cruz, Ministério da Saúde 01.06.2017
Fundação Oswaldo Cruz (FIOCRUZ)
Subjects
Adult
Animals
Antigens, Helminth - analysis
Cross-Sectional Studies
diagnosis
Female
Humans
infectious diseases
international health
Italy
Male
Middle Aged
PARASITOLOGY
Reproducibility of Results
Schistosoma mansoni - immunology
schistosomiasis
Schistosomiasis mansoni - diagnosis
Sensitivity and Specificity
Short Communication
Transients and Migrants - statistics & numerical data
travel medicine
TROPICAL MEDICINE
diagnosis
schistosomiasis
travel medicine
tropical medicine
infectious diseases
international health
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Summary:Diagnosis of schistosomiasis in migrants coming from endemic areas can be difficult, especially in asymptomatic subjects. Light-intensity disease, in fact, may be missed due to the low sensitivity of the stool microscopy and serologic testing cannot distinguish between a resolved infection and an active infection in patients who have been infected and treated in the past, because specific antibodies can persist despite cure. We describe a cross-sectional study conducted on 82 migrants tested for Schistosoma mansoni on single blood (anti-schistosome antibodies, total IgE) and urine [point-of-care (POC) circulating-cathodic-antigen (CCA) test] samples. A positive POC-CCA test (active infection) resulted in two untreated patients with a positive serology while all patients (n = 66) with a past infection showed a negative POC-CCA test. POC-CCA urine test in combination with serology may be helpful in rapidly differentiate active from past S. mansoni infection in migrants coming from endemic areas.
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AUTHORS’ CONTRIBUTION
GG, AnC and AL - Designed the study; GG, AS, SC, AlC, AB and NC - participated in the conduction of the study; LG, LI and GG - analysed the data; LG, LI, SC, AlC and GG - contributed to the interpretation of the data; LI and LG - wrote the first draft of the paper; AnC, GG, SC and AlC - contributed in the writing of the paper. All authors read and approved the final manuscript. GG is guarantor of the paper.
ISSN:0074-0276
1678-8060
0074-0276
1678-8060
DOI:10.1590/0074-02760160355