FOXP3 ＋ regulatory T cells and their functional regulation

FOXP3＋ regulatory T （Treg） cells are critical in maintaining immune tolerance and homeostasis of the immune system. The molecular mechanisms underlying the stability, plasticity and functional activity of Treg cells have been much studied in recent years. Here, we summarize these intriguing findings...

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Bibliographic Details
Published inCellular & molecular immunology Vol. 12; no. 5; pp. 558 - 565
Main Authors Li, Zhiyuan, Li, Dan, Tsun, Andy, Li, Bin
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.09.2015
Nature Publishing Group
Subjects
Animals
Antibodies
Autoimmune diseases
Biomedical and Life Sciences
Biomedicine
Cell therapy
Clinical Trials as Topic
Forkhead Transcription Factors - metabolism
Foxp3 protein
Functional plasticity
Graft-versus-host reaction
Homeostasis
Humans
Immune system
Immunological tolerance
Immunology
Immunoregulation
Lymphocytes T
Medical Microbiology
Microbiology
Molecular modelling
Protein Processing, Post-Translational
Review
T-Lymphocytes, Regulatory - immunology
Vaccine
免疫系统
免疫耐受
分子机制
功能调控
潜在用途
移植物抗宿主病
自身免疫性疾病
调节性T细胞
autoimmune diseases
Treg cells
immunosuppressive activity
FOXP3
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Summary:FOXP3＋ regulatory T （Treg） cells are critical in maintaining immune tolerance and homeostasis of the immune system. The molecular mechanisms underlying the stability, plasticity and functional activity of Treg cells have been much studied in recent years. Here, we summarize these intriguing findings, and provide insight into their potential use or manipulation during Treg cell therapy for the treatment of autoimmune diseases, graft-versus-host disease （GVHD） and cancer.
Bibliography:11-4987/R
FOXP3＋ regulatory T （Treg） cells are critical in maintaining immune tolerance and homeostasis of the immune system. The molecular mechanisms underlying the stability, plasticity and functional activity of Treg cells have been much studied in recent years. Here, we summarize these intriguing findings, and provide insight into their potential use or manipulation during Treg cell therapy for the treatment of autoimmune diseases, graft-versus-host disease （GVHD） and cancer.
autoimmune diseases; FOXP3; immunosuppressive activity; Treg cells
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1672-7681
2042-0226
DOI:10.1038/cmi.2015.10