Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal

• Published in: World journal of gastroenterology : WJG Vol. 15; no. 28; pp. 3560 - 3564
• Main Authors: Colvin, Marni, Delis, Aris, Bracamonte, Erika, Villar, Hugo, Leon, Jr, Luis R
• Format: Journal Article
• Language: English
• Published: United States Department of Surgical Oncology, University Medical Center, Tucson, AZ 85724, United States%Department of Pathology, University Medical Center, Tucson, AZ 85724, United States%Department of Vascular Surgery, Tucson Medical Center, Tucson, AZ 85712 28.07.2009; Department of Vascular Surgery, University Medical Center, Tucson, AZ 85724, United States; The WJG Press
• Subjects: Adenocarcinoma - pathology; Adenocarcinoma - surgery; Adenoma, Villous - pathology; Adenoma, Villous - surgery; Aged, 80 and over; Anal Canal - pathology; Anal Canal - surgery; Case Report; Cell Transformation, Neoplastic - pathology; Disease Progression; Humans; Male; Treatment Outcome; 切除术; 恶性肿瘤; 浸润性; 消化道; 间歇性; Villous adenoma; Anal adenocarcinoma; Anal canal
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.15.3560

Primary neoplasms arising in the anal canal are relatively unusual. In particular, adenomas and adenocarcinomas are distinctly rare entities in this region. We describe an infiltrating, well-differentiated adenocarcinoma arising in a villous adenoma from the distal anal canal, in an otherwise healthy patient at low risk for gastrointestinal malignancy. This is the case of an octogenarian man with a several year history of hemorrhoids and intermittent rectal bleeding, more recently complaining of continuous hematochezia. Examination revealed a blood-covered pedunculated mass with a long stalk protruding from the anus. The lesion was amputated at the bedside. Microscopic evaluation revealed an infiltrating well-differentiated adenocarcinoma, arising from a villous adenoma. This was further evaluated under anesthesia and complete excision of distal anal tissue was performed. Our report is the first describing the possible malignant degeneration of a villous adenoma in the anal canal.