Barnes Maze Procedure for Spatial Learning and Memory in Mice

The Barnes maze is a dry-land based rodent behavioral paradigm for assessing spatial learning and memory that was originally developed by its namesake, Carol Barnes. It represents a well-established alternative to the more popular Morris Water maze and offers the advantage of being free from the pot...

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Bibliographic Details
Published inBio-protocol Vol. 8; no. 5
Main Author Pitts, Matthew W
Format Journal Article
LanguageEnglish
Published United States Bio-Protocol 05.03.2018
Bio-protocol LLC
Subjects
Biology
Methods
Cognition
Behavior
Mouse
Hippocampus
Spatial memory
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Summary:The Barnes maze is a dry-land based rodent behavioral paradigm for assessing spatial learning and memory that was originally developed by its namesake, Carol Barnes. It represents a well-established alternative to the more popular Morris Water maze and offers the advantage of being free from the potentially confounding influence of swimming behavior. Herein, the Barnes maze experimental setup and corresponding procedures for testing and analysis in mice are described in detail.
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ISSN:2331-8325
2331-8325
DOI:10.21769/bioprotoc.2744