A novel polysaccharide from mycelia of cultured Phellinus linteus displays antitumor activity through apoptosis

• Published in: Carbohydrate polymers Vol. 124; pp. 90 - 97
• Main Authors: Mei, Yuxia, Zhu, Hai, Hu, Qiming, Liu, Yangyang, Zhao, Shumiao, Peng, Nan, Liang, Yunxiang
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 25.06.2015
• Subjects: Animals; antineoplastic activity; antineoplastic agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - therapeutic use; Antitumor activity; Apoptosis; Apoptosis - drug effects; cellulose; Fourier transform infrared spectroscopy; Fungal Polysaccharides - chemistry; Fungal Polysaccharides - isolation & purification; Fungal Polysaccharides - therapeutic use; gas chromatography-mass spectrometry; methylation; Mice; mycelium; Mycelium - chemistry; neoplasm cells; nuclear magnetic resonance spectroscopy; oxidation; Phellinus linteus; Plant Extracts; Polysaccharides; Polysaccharides - chemistry; Polysaccharides - isolation & purification; Polysaccharides - therapeutic use; Sarcoma 180 - drug therapy; Structural analysis; Phellinus linteus; Antitumor activity; Polysaccharides; Structural analysis; Apoptosis

•PLPS-1 and -2 were purified from mycelia of Phellinus linteus.•The structures of the two polysaccharides were elucidated to be quite different.•Only PLPS-1 displayed anti-proliferative effect against S-180 cells.•PLPS-1 induced apoptosis of S-180 cells in a dose-dependent manner.•The difference in...