The microbiota–gut–brain axis and its potential therapeutic role in autism spectrum disorder

• Published in: Neuroscience Vol. 324; pp. 131 - 139
• Main Authors: Li, Q, Zhou, J.-M
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 02.06.2016
• Subjects: Animals; autism spectrum disorder; Autism Spectrum Disorder - microbiology; Autism Spectrum Disorder - therapy; brain; Brain - microbiology; Gastrointestinal Microbiome - physiology; Humans; microbial metabolites; microbiota; Neurology; probiotics; BBB; CHD8; blood–brain barrier; tetanus neurotoxin; maternal immune activation; GF/CF; autism spectrum disorder; Trichuris suis ova; AA; MIA; gamma-aminobutyric acid; VA; inflammatory bowel disease; central nervous system; valeric acid; germ-free; gastrointestinal; TeNT; TSO; microbial metabolites; CRH; GABA; HPA; 4-ethylphenylsulfate; 5-HT; probiotics; PPA; microbiota; 5-hydroxytryptamine; ANS; WAS; CNS; IBD; ENS; 4EPS; propionic acid; ASD; chromodomain helicase DNA-binding protein 8; water-avoidance stress; ketogenic diet; KD; IBS; GF; gluten-free, casein-free; corticotropin-releasing hormone; GI; autonomic nervous system; irritable bowel syndrome; brain; hypothalamus–pituitary–adrenal; acetic acid; SCFAs; enteric nervous system; short-chain fatty acids
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2016.03.013

Highlights • The microbiota–gut–brain axis is a bidirectional neurohumoral communication system. • Autistic neurodevelopmental deficits are frequently associated with gastrointestinal symptoms and gut microbiota dysbiosis. • Disturbance of the gut microbiota has been implicated as a possible contributor to ASD behavioral deficits. • Modulating the microbiota–gut–brain axis is a promising strategy for treatment of ASD symptoms.