The role of dendritic cells in asthma

• Published in: Journal of allergy and clinical immunology Vol. 129; no. 4; pp. 889 - 901
• Main Author: Gill, Michelle Ann, MD, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.2012; Elsevier; Elsevier Limited
• Subjects: Accreditation; Airway management; allergen; Allergens; Allergens - immunology; Allergies; Allergy and Immunology; Animals; Asthma; Asthma - immunology; Asthma - metabolism; Asthma - therapy; Biological and medical sciences; Chemokines; Chronic obstructive pulmonary disease, asthma; Dendritic cells; Dendritic Cells - immunology; Dendritic Cells - metabolism; Disease; Disease Models, Animal; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Human subjects; Humans; Hypersensitivity; Immune system; Immunoglobulin E - immunology; Immunological tolerance; Immunopathology; Inflammation - immunology; Inflammation - metabolism; Interferon-alpha - metabolism; Lung - cytology; Lung - immunology; Lung - metabolism; Lymphocytes; Medical sciences; Molecular Targeted Therapy; Participation; Pneumology; Recruitment; Rodents; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Th2 Cells - immunology; TH2 inflammation; Viruses - immunology; PAR; allergen; Matrix metalloproteinase 9; OX40L; Thymus and activation-regulated chemokine; Plasmacytoid dendritic cell; HDM; OX40 ligand; IDO; Myeloid dendritic cell; TNF-related apoptosis-inducing ligand; TLR; Immunoglobulin-like transcript 7; WT; Toll-like receptor; Dendritic cell; Ovalbumin; T H2 inflammation; cDC; TRAIL; Dendritic cells; ILT7; TSLP; Blood dendritic cell antigen; Conventional dendritic cell; BALF; asthma; House dust mite; mDC; pDC; Wild-type; Signal regulatory protein α; Thymic stromal lymphopoietin; SIRP-α; Bronchoalveolar lavage fluid; Indoleamine 2,3-dioxygenase; TARC; OVA; Protease-activated receptor; MMP-9; BDCA; DC; TH2 inflammation; Lung disease; Allergy; Immunopathology; Respiratory disease; Inflammation; Asthma; 2 inflammation; Immunology; T; Antigen presenting cell; T-Lymphocyte; Bronchus disease; Th2 lymphocyte; Obstructive pulmonary disease; Allergen
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2012.02.028

Dendritic cells (DCs) are known to play a central role in sensing the presence of foreign antigens and infectious agents and in initiating appropriate immune responses. More recently, an additional role has been discovered for DCs in determining whether the response to potential environmental allergens will be one of tolerance or whether a vigorous response along allergic pathways will be initiated. This review discusses ways in which DCs participate specifically in initiating allergic responses, particularly those associated with allergic asthma, and how interventions focused on DCs might lead to new therapeutic approaches to asthma.