Hepatoprotective Effect of Aged Black Garlic Extract in Rodents

• Published in: Toxicological research (Seoul) Vol. 30; no. 1; pp. 49 - 54
• Main Authors: Shin, Jung Hyu, Lee, Chang Woo, Oh, Soo Jin, Yun, Jieun, Kang, Moo Rim, Han, Sang-Bae, Park, Heungsik, Jung, Jae Chul, Chung, Yoon Hoo, Kang, Jong Soon
• Format: Journal Article
• Language: English
• Published: Singapore 한국독성학회 01.03.2014; Springer Singapore; The Korean Society Of Toxicology
• Subjects: Biomedicine; Original Article; Pharmacology/Toxicology; 예방의학; Aged black garlic; D-galactosamine; Non-alcoholic fatty liver disease; Carbon tetrachloride; Liver injury
• ISSN: 1976-8257; 2234-2753
• DOI: 10.5487/TR.2014.30.1.049

In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamine-induced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury.