Advances in phenylboronic acid-based closed-loop smart drug delivery system for diabetic therapy

There are many patients with diabetes in the world and the treatment of diabetes is still a hectic problem, which has a nagative impact on the life of diabetic patients. A lot of research has been done on this, among which the phenylboronic acid-based smart drug delivery system mimics the working mo...

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Published inJournal of controlled release Vol. 305; pp. 50 - 64
Main Authors Huang, Qiao, Wang, Li, Yu, Haojie, Ur-Rahman, Kaleem
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 10.07.2019
Subjects
blood glucose
Closed-loop system
diabetes
Drug delivery
drug delivery systems
gels
humans
Insulin
micelles
microstructure
patients
Phenylboronic acid
Phenylboronic acid
Closed-loop system
Drug delivery
Insulin
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Abstract There are many patients with diabetes in the world and the treatment of diabetes is still a hectic problem, which has a nagative impact on the life of diabetic patients. A lot of research has been done on this, among which the phenylboronic acid-based smart drug delivery system mimics the working mode of human islets. When it is injected into the human body, it automatically releases the corresponding amount of insulin according to the blood glucose level of the human body. Such drug delivery systems can be divided into gels, micelles, capsules and vesicles, etc. according to the microstructure. This paper mainly highlights the recent progress in this field. [Display omitted]
AbstractList There are many patients with diabetes in the world and the treatment of diabetes is still a hectic problem, which has a nagative impact on the life of diabetic patients. A lot of research has been done on this, among which the phenylboronic acid-based smart drug delivery system mimics the working mode of human islets. When it is injected into the human body, it automatically releases the corresponding amount of insulin according to the blood glucose level of the human body. Such drug delivery systems can be divided into gels, micelles, capsules and vesicles, etc. according to the microstructure. This paper mainly highlights the recent progress in this field.
There are many patients with diabetes in the world and the treatment of diabetes is still a hectic problem, which has a nagative impact on the life of diabetic patients. A lot of research has been done on this, among which the phenylboronic acid-based smart drug delivery system mimics the working mode of human islets. When it is injected into the human body, it automatically releases the corresponding amount of insulin according to the blood glucose level of the human body. Such drug delivery systems can be divided into gels, micelles, capsules and vesicles, etc. according to the microstructure. This paper mainly highlights the recent progress in this field.There are many patients with diabetes in the world and the treatment of diabetes is still a hectic problem, which has a nagative impact on the life of diabetic patients. A lot of research has been done on this, among which the phenylboronic acid-based smart drug delivery system mimics the working mode of human islets. When it is injected into the human body, it automatically releases the corresponding amount of insulin according to the blood glucose level of the human body. Such drug delivery systems can be divided into gels, micelles, capsules and vesicles, etc. according to the microstructure. This paper mainly highlights the recent progress in this field.
There are many patients with diabetes in the world and the treatment of diabetes is still a hectic problem, which has a nagative impact on the life of diabetic patients. A lot of research has been done on this, among which the phenylboronic acid-based smart drug delivery system mimics the working mode of human islets. When it is injected into the human body, it automatically releases the corresponding amount of insulin according to the blood glucose level of the human body. Such drug delivery systems can be divided into gels, micelles, capsules and vesicles, etc. according to the microstructure. This paper mainly highlights the recent progress in this field. [Display omitted]
Author Ur-Rahman, Kaleem
Yu, Haojie
Wang, Li
Huang, Qiao
Author_xml – sequence: 1
  givenname: Qiao
  surname: Huang
  fullname: Huang, Qiao
  email: 21828145@zju.edu.cn
– sequence: 2
  givenname: Li
  orcidid: 0000-0001-9356-9930
  surname: Wang
  fullname: Wang, Li
  email: opl_wl@dial.zju.edu.cn
– sequence: 3
  givenname: Haojie
  surname: Yu
  fullname: Yu, Haojie
  email: hjyu@zju.edu.cn
– sequence: 4
  givenname: Kaleem
  surname: Ur-Rahman
  fullname: Ur-Rahman, Kaleem
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31112719$$D View this record in MEDLINE/PubMed
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Keywords Phenylboronic acid
Closed-loop system
Drug delivery
Insulin
Language English
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Snippet There are many patients with diabetes in the world and the treatment of diabetes is still a hectic problem, which has a nagative impact on the life of diabetic...
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SubjectTerms blood glucose
Closed-loop system
diabetes
Drug delivery
drug delivery systems
gels
humans
Insulin
micelles
microstructure
patients
Phenylboronic acid
Title Advances in phenylboronic acid-based closed-loop smart drug delivery system for diabetic therapy
URI https://dx.doi.org/10.1016/j.jconrel.2019.05.029
https://www.ncbi.nlm.nih.gov/pubmed/31112719
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