Advances in phenylboronic acid-based closed-loop smart drug delivery system for diabetic therapy

There are many patients with diabetes in the world and the treatment of diabetes is still a hectic problem, which has a nagative impact on the life of diabetic patients. A lot of research has been done on this, among which the phenylboronic acid-based smart drug delivery system mimics the working mo...

Full description

Saved in:
Bibliographic Details
Published inJournal of controlled release Vol. 305; pp. 50 - 64
Main Authors Huang, Qiao, Wang, Li, Yu, Haojie, Ur-Rahman, Kaleem
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 10.07.2019
Subjects
blood glucose
Closed-loop system
diabetes
Drug delivery
drug delivery systems
gels
humans
Insulin
micelles
microstructure
patients
Phenylboronic acid
Phenylboronic acid
Closed-loop system
Drug delivery
Insulin
Online AccessGet full text

Cover

More Information
Summary:There are many patients with diabetes in the world and the treatment of diabetes is still a hectic problem, which has a nagative impact on the life of diabetic patients. A lot of research has been done on this, among which the phenylboronic acid-based smart drug delivery system mimics the working mode of human islets. When it is injected into the human body, it automatically releases the corresponding amount of insulin according to the blood glucose level of the human body. Such drug delivery systems can be divided into gels, micelles, capsules and vesicles, etc. according to the microstructure. This paper mainly highlights the recent progress in this field. [Display omitted]
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0168-3659
1873-4995
1873-4995
DOI:10.1016/j.jconrel.2019.05.029