Dysregulation of the CD147 complex confers defective placental development: A pathogenesis of early‐onset preeclampsia

• Published in: Clinical and translational medicine Vol. 12; no. 6; pp. e826 - n/a
• Main Authors: Lee, Cheuk‐Lun, Chen, Zhilong, Zhang, Qingqing, Guo, Yue, Ng, Vivian W.Y., Zhang, Baozhen, Bai, Kunfeng, Ruan, Degong, Kan, Anita S.Y., Cheung, Ka‐Wang, Mak, Annisa S.L., Yeung, William S.B., Su, Rui, Yang, Qing, Chen, Min, Du, Mei‐Rong, Jian, Zhang, Fan, Xiujun, Chiu, Philip C.N.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.06.2022; John Wiley and Sons Inc; Wiley
• Subjects: Biomarkers; Conflicts of interest; Female; Humans; Letter to Editor; Pathogenesis; Pathophysiology; Placenta; Placenta - pathology; Pre-Eclampsia - etiology; Pre-Eclampsia - pathology; Preeclampsia; Pregnancy; Proteins; Veins & arteries
• ISSN: 2001-1326; 2001-1326
• DOI: 10.1002/ctm2.826

PE is a multifactorial gestational complication affecting 4.6% of pregnancies worldwide.1 It is the top cause of prenatal morbidity/mortality and is associated with a high incidence of maternal and perinatal complications, causing a heavy burden to the healthcare system.1 The aetiology of PE is associated with defective trophoblast differentiation and functions causing abnormal placental development, insufficient placental perfusion, and maternal–foetal exchange defects.1,2 Our limited knowledge of the pathogenesis of the disease has hindered the development of a reliable approach for the prediction and treatment of PE. [...]renal damage including glomerular capillary endotheliosis and glomerular erythropenia (Figure 1I) and deterioration of development in terms of placental diameter and thickness, biparietal diameter, crown-rump length and foetal heart rate (Figure 1J) were observed in the knockdown mice. Suppression of CD147 functions by functional blocking antibody8 (Table S1) and siRNA (Figure S5) or stimulation of CD147 by ligation antibody9 (Table S1) showed that trophoblastic CD147 regulated characteristic features of the vascular remodelling process in early human pregnancy, including EVCT invasiveness and MMP2 expression/activity (Figure 3A,B), integration of EVCT into the endothelial network (Figure 3C), and endothelial cell angiogenesis (Figure 3D) and permeability (Figure 3E).