Localized skin‐limited blastic plasmacytoid dendritic cell neoplasm

Immunohistochemical analysis showed cells that were positive for CD4, CD56, CD123, SPIB, TdT, and negative for MNDA (Figure 4), which supported the diagnosis of blastic plasmacytoid dendritic-cell neoplasm (BPDCN). The clinical features and evolution consist of two main patterns: (A) Indolent onset...

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Published inEJHaem Vol. 3; no. 2; pp. 560 - 562
Main Authors Suárez, Edwin U., Cornago, Javier, Piris, Miguel Á., Rodriguez Pinilla, Socorro M., López‐Lorenzo, José L., Soto, Carlos
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.05.2022
John Wiley and Sons Inc
Wiley
Subjects
Biopsy
Bone marrow
CD123 antigen
CD4 antigen
CD56 antigen
Computed tomography
Conflicts of interest
Dendritic cells
DNA nucleotidylexotransferase
Haematology Images
Mutation
Skin
Skin diseases
Skin lesions
Tumors
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Summary:Immunohistochemical analysis showed cells that were positive for CD4, CD56, CD123, SPIB, TdT, and negative for MNDA (Figure 4), which supported the diagnosis of blastic plasmacytoid dendritic-cell neoplasm (BPDCN). The clinical features and evolution consist of two main patterns: (A) Indolent onset dominate by skin lesions followed by tumor dissemination (70–90%) and (B) Acute leukemia features with systemic involvement from the beginning (10-30%) [ 1, 2]. 18(F)–FDG-PET-CT imaging show lesion with oval morphology and well-defined borders (44 × 18 × 53 mm) with pathological uptake ACKNOWLEDGMENTS This work was supported by grants from the Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Economy and Competence (MINECO, FEDER, RTICC ISCIII, and Centro de Investigación Biomédica en Red Cáncer - CIBERONC) (SAF2013-47416-R, RD06/0020/0107-RD012/0036/0060, and Plan Nacional I+D+I:
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ISSN:2688-6146
2688-6146
DOI:10.1002/jha2.383