A Human Lymph Node In Vitro-Challenges and Progress

:  Extracorporeal human lymphatic organs are expected to be excellent tools in the study of human molecular and cellular bases of the immunologic balance and tissue harmony. A rational approach and process to design a device and a procedure to recreate the human lymph node environment in vitro is de...

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Published inArtificial organs Vol. 30; no. 10; pp. 803 - 808
Main Authors Giese, Christoph, Demmler, Christian D., Ammer, Richard, Hartmann, Stefan, Lubitz, Annika, Miller, Lilja, Müller, Riccarda, Marx, Uwe
Format Journal Article
LanguageEnglish
Published Malden, USA Blackwell Publishing Inc 01.10.2006
Subjects
Bioreactor
Bioreactors
Cell Differentiation
Gels
Human
Humans
Lymph node
Lymph Nodes - cytology
Organoids - cytology
Porous matrix
Regeneration
Tissue culture
Tissue Engineering - methods
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Summary::  Extracorporeal human lymphatic organs are expected to be excellent tools in the study of human molecular and cellular bases of the immunologic balance and tissue harmony. A rational approach and process to design a device and a procedure to recreate the human lymph node environment in vitro is described with emphasis on T‐cell activation. Based on this approach, a bioreactor and a process supporting self‐assembly of human lymphatic tissues due to proper emulation of human architecture and homeostasis could be developed.
Bibliography:ArticleID:AOR303
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Presented in part at the 43rd Tutzing Symposium “Regenerative Medicine—Membranes & Scaffolds” held November 20–23, 2005, in Tutzing, Germany.
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ISSN:0160-564X
1525-1594
DOI:10.1111/j.1525-1594.2006.00303.x