Immunohistochemical determination of immunosuppressive acidic protein in reactive and neoplastic diseases of macrophage

Immunosuppressive acidic protein (IAP), a substance purified from cancer ascitic fluid, is released into the culture medium of macrophages and neutrophils, and is supposed to suppress an immune function of the host. Elevation of serum IAP in cancer patients has been reported. In the current study, p...

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Published inCancer Vol. 60; no. 10; pp. 2424 - 2427
Main Authors Aozasa, Katsuyuki, Ueda, Takafumi, Ayata, Masahiro, Tsujimoto, Masahiko, Fujita, Masaki Q., Yamamura, Teiichi, Tsujimura, Takahiro
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 15.11.1987
Wiley-Liss
Subjects
Biological and medical sciences
Hematologic and hematopoietic diseases
Histiocytoma, Benign Fibrous - pathology
Immunoenzyme Techniques
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphatic Diseases - pathology
Macrophages - analysis
Medical sciences
Neoplasm Proteins - analysis
Neutrophils - analysis
Panniculitis, Nodular Nonsuppurative - pathology
Skin Neoplasms - pathology
Tuberculosis, Lymph Node - pathology
Human
Immunohistochemistry
Acidic protein
Malignant histiocytoma
Malignant histiocytosis
Biological marker
Tumor
Hemopathy
Histiocytosis
Reticulosis
Macrophage
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Summary:Immunosuppressive acidic protein (IAP), a substance purified from cancer ascitic fluid, is released into the culture medium of macrophages and neutrophils, and is supposed to suppress an immune function of the host. Elevation of serum IAP in cancer patients has been reported. In the current study, presence of IAP in proliferating diseases of macrophage was examined. Macrophages in reactive proliferation, histiocytosis X, and neoplastic proliferation gave positive reaction for IAP. Diffuse cytoplasmic staining was usual, but dot‐like or globular and surface staining also were observed. Proliferating cells in malignant fibrous histiocytoma were more sensitively stained by IAP than by other ordinary used markers for macrophage. These findings provide useful information to understand the mechanism of elevation of serum IAP in cancer patients.
Bibliography:ObjectType-Article-1
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ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19871115)60:10<2424::AID-CNCR2820601012>3.0.CO;2-2