Pyroptosis, metabolism, and tumor immune microenvironment

• Published in: Clinical and translational medicine Vol. 11; no. 8; pp. e492 - n/a
• Main Authors: Du, Tiantian, Gao, Jie, Li, Peilong, Wang, Yunshan, Qi, Qiuchen, Liu, Xiaoyan, Li, Juan, Wang, Chuanxin, Du, Lutao
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.08.2021; John Wiley and Sons Inc; Wiley
• Subjects: Acids; Apoptosis; Clinical medicine; Cytokines; gasdermin; Humans; Immune system; Infections; Kinases; Melanoma; metabolism; Mitochondrial DNA; Mutation; Neoplasms - immunology; Neoplasms - microbiology; Neutrophils; Pattern recognition; Proteins; pyroptosis; Pyroptosis - physiology; Review; Reviews; tumor immunity; tumor microenvironment; Tumor Microenvironment - physiology; Tumor necrosis factor-TNF; pyroptosis; gasdermin; metabolism; tumor immunity; tumor microenvironment

In response to a wide range of stimulations, host cells activate pyroptosis, a kind of inflammatory cell death which is provoked by the cytosolic sensing of danger signals and pathogen infection. In manipulating the cleavage of gasdermins (GSDMs), researchers have found that GSDM proteins serve as t...