Pyroptosis, metabolism, and tumor immune microenvironment

In response to a wide range of stimulations, host cells activate pyroptosis, a kind of inflammatory cell death which is provoked by the cytosolic sensing of danger signals and pathogen infection. In manipulating the cleavage of gasdermins (GSDMs), researchers have found that GSDM proteins serve as t...

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Published inClinical and translational medicine Vol. 11; no. 8; pp. e492 - n/a
Main Authors Du, Tiantian, Gao, Jie, Li, Peilong, Wang, Yunshan, Qi, Qiuchen, Liu, Xiaoyan, Li, Juan, Wang, Chuanxin, Du, Lutao
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.08.2021
John Wiley and Sons Inc
Wiley
Subjects
Acids
Apoptosis
Clinical medicine
Cytokines
gasdermin
Humans
Immune system
Infections
Kinases
Melanoma
metabolism
Mitochondrial DNA
Mutation
Neoplasms - immunology
Neoplasms - microbiology
Neutrophils
Pattern recognition
Proteins
pyroptosis
Pyroptosis - physiology
Review
Reviews
tumor immunity
tumor microenvironment
Tumor Microenvironment - physiology
Tumor necrosis factor-TNF
pyroptosis
gasdermin
metabolism
tumor immunity
tumor microenvironment
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Summary:In response to a wide range of stimulations, host cells activate pyroptosis, a kind of inflammatory cell death which is provoked by the cytosolic sensing of danger signals and pathogen infection. In manipulating the cleavage of gasdermins (GSDMs), researchers have found that GSDM proteins serve as the real executors and the deterministic players in fate decisions of pyroptotic cells. Whether inflammatory characteristics induced by pyroptosis could cause damage the host or improve immune activity is largely dependent on the context, timing, and response degree. Here, we systematically review current points involved in regulatory mechanisms and the multidimensional roles of pyroptosis in several metabolic diseases and the tumor microenvironment. Targeting pyroptosis may reveal potential therapeutic avenues. Gasdermins are executors of pyroptosis, which cause inflammatory cell death, accompanied with various inflammatory mediators. Pyroptosis plays a dual role in tumor microenvironment, including anti‐tumor and pro‐tumor effects. Pyroptosis can be used as a new target to fight against the tumor.
Bibliography:These authors contributed equally to this work.
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ISSN:2001-1326
2001-1326
DOI:10.1002/ctm2.492