Toll-deficient Drosophila is susceptible to Pythium insidiosum infection

There is a paucity of animal models of pythiosis, a life-threatening disease of humans and animals, the immunopathogenesis of which is poorly understood. A pythiosis model was developed by injecting Toll (Tl)-deficient Drosophila melanogaster flies with Pythium insidiosum zoospores. The infected Tl...

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Published inMicrobiology and immunology Vol. 57; no. 10; p. 732
Main Authors Zanette, Régis A, Santurio, Janio M, Loreto, Érico S, Alves, Sydney H, Kontoyiannis, Dimitrios P
Format Journal Article
LanguageEnglish
Published Australia 01.10.2013
Subjects
Animals
Disease Models, Animal
Drosophila melanogaster - immunology
Drosophila melanogaster - parasitology
Drosophila Proteins - deficiency
Drosophila Proteins - immunology
Pythium - growth & development
Pythium - immunology
Survival Analysis
Toll-Like Receptors - deficiency
Toll-Like Receptors - immunology
mini-host models
Toll receptors
pythiosis
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Summary:There is a paucity of animal models of pythiosis, a life-threatening disease of humans and animals, the immunopathogenesis of which is poorly understood. A pythiosis model was developed by injecting Toll (Tl)-deficient Drosophila melanogaster flies with Pythium insidiosum zoospores. The infected Tl mutant flies had significantly lower survival rates (73.7%) than did control flies. This study reveals the important role of Tl pathway activation in fly immune response to pythiosis.
ISSN:1348-0421
DOI:10.1111/1348-0421.12082