Reversal of autoimmune hemolytic anemia associated with chronic lymphocytic leukemia following high‐dose immunoglobulin

An 85‐year‐old man with chronic lymphocytic leukemia developed severe warm antibody‐type autoimmune hemolytic anemia. Initial therapy with high‐dose corticosteroids had no discernible effect on the hemolytic process. Following treatment with high‐dose intravenous immunoglobulin (0.4 g/kg/d for 5 con...

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Bibliographic Details
Published inCancer Vol. 60; no. 11; pp. 2637 - 2640
Main Authors Ritch, Paul S., Anderson, Tom
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.12.1987
Wiley-Liss
Subjects
Aged
Aged, 80 and over
Anemia, Hemolytic, Autoimmune - therapy
Biological and medical sciences
Hematologic and hematopoietic diseases
Humans
Immunization, Passive
Leukemia, Lymphoid - complications
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Prednisone - therapeutic use
Purpura, Thrombocytopenic - therapy
Human
Immunoglobulins
Chronic lymphocytic leukemia
Hemolytic anemia
Intravenous administration
Immunotherapy
Autoimmune disease
Hemopathy
High dose
Elderly
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Summary:An 85‐year‐old man with chronic lymphocytic leukemia developed severe warm antibody‐type autoimmune hemolytic anemia. Initial therapy with high‐dose corticosteroids had no discernible effect on the hemolytic process. Following treatment with high‐dose intravenous immunoglobulin (0.4 g/kg/d for 5 consecutive days) there was an immediate and sustained increase in hematocrit accompanied by a progressive decline in reticulocyte count. A review of the literature reveals that some patients with steroid‐resistant immune hemolysis may benefit from high‐dose immunoglobulin. This approach should be considered in elderly patients with severe anemia whose medical status precludes splenectomy.
Bibliography:ObjectType-Case Study-2
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ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19871201)60:11<2637::AID-CNCR2820601111>3.0.CO;2-S