Nuclear and cellular volumetric alterations in oral lichen planus and lichenoid lesions : a histomorphometric study

• Published in: Journal of Oral Science Vol. 43; no. 3; pp. 151 - 157
• Main Authors: Khoo, Suan-Phaik, Primasari, Ameta, Saub, Roslan
• Format: Journal Article
• Language: English
• Published: Japan Nihon University School of Dentistry 2001
• Subjects: Adult; Case-Control Studies; Cell Nucleus - pathology; Cell Size; cellular volumes; Dentistry; Diagnosis, Differential; Epithelial Cells - pathology; Female; Humans; Lichen Planus, Oral - pathology; Lichenoid Eruptions - pathology; Lupus Erythematosus, Discoid - pathology; Male; Middle Aged; Mouth Mucosa - pathology; nuclear; oral lichenoid lesions; Retrospective Studies
• ISSN: 1343-4934; 1880-4926
• DOI: 10.2334/josnusd.43.151

There is presently no line of distinction between oral lichen planus and other oral lichenoid lesions. The aim of this study is to determine using histomorphometry, the differences between these lesions. Paraffin sections from 7 normal buccal epithelium, 19 oral lichen planus (LP), 14 oral lichenoid lesions (LL) and 7 discoid lupus erythematosus-like lesions (DLE-II) were selected. The nuclear volume (VN) and cellular-volume (VCELL) of the epithelium were assessed using an image analyser. The VN and VCELL derived for both basal and spinal strata in LP and DLE-II were 2.3 times more than that of normal tissues. There was a significant difference between LP and LL (P<0.005) and between LL and DLE-II (P<0.001), but not between LP and DLE-II. In conclusion, there appears to be a difference between LP, LL and DLE-II and VN and VCELL may serve as potential discriminators between these groups of lesions. (J. Oral Sci. 43, 151-157, 2001)