Anaphylaxis to apple and orange seed

• Published in: Journal of allergy and clinical immunology Vol. 128; no. 6; pp. 1363 - 1365
• Main Authors: Turner, Paul J., FRACP, PhD, Gray, Paul E.A., FRACP, Wong, Melanie, FRACP, PhD, Varese, Nirupama, MSc, Rolland, Jennifer M., PhD, O’Hehir, Robyn, FRACP, PhD, Campbell, Dianne E., FRACP, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2011; Elsevier; Elsevier Limited
• Subjects: Allergens - immunology; Allergies; Allergy and Immunology; Apples; Baby foods; Biological and medical sciences; Citrus sinensis - immunology; Female; Food Hypersensitivity - immunology; Fruit - immunology; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Immunopathology; Male; Medical sciences; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Seeds; Allergy; Immunopathology; Apple; Anaphylaxis; Seeds; Immunology
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2011.07.005

To the Editor: Childhood fruit allergy is relatively common, with up to 3% of 3-year-olds having allergy to citrus fruit,1 the best-studied example being oranges.2 Susceptible subjects generally present with symptoms of oral allergy syndrome (also known as pollen-food syndrome) with associated pollen sensitization.3 Although there are a limited number of reports of patients reacting to citrus seeds in the absence of clinical reactivity to fruit pulp/peel,4,5 there are no previous reports of apple seed allergy. To further characterize the nature of the allergy in this third patient, we prepared extracts of peel/pulp and seeds from Granny Smith apples, peanut, and sesame seed, as previously described.7 We also attempted extraction of the apple and oat baby food.