Familial chylomicronemia syndrome related chronic pancreatitis: a single-center study

• Published in: Hepatobiliary & pancreatic diseases international Vol. 13; no. 2; pp. 209 - 214
• Main Authors: Sisman, Gurhan, Erzin, Yusuf, Hatemi, Ibrahim, Caglar, Erkan, Boga, Salih, Singh, Vikesh, Senturk, Hakan
• Format: Journal Article
• Language: English
• Published: Singapore Elsevier B.V 01.04.2014
• Subjects: Adolescent; Adult; Age Factors; Biomarkers - blood; Chi-Square Distribution; Child; Cholangiopancreatography, Endoscopic Retrograde; chronic; chronic pancreatitis; Endocrinology & Metabolism; Endosonography; Female; Gastroenterology and Hepatology; Humans; hyperlipidemia; Hyperlipoproteinemia Type I - blood; Hyperlipoproteinemia Type I - complications; Hyperlipoproteinemia Type I - diagnosis; Logistic Models; Male; Middle Aged; Odds Ratio; pancreatitis; Pancreatitis, Chronic - diagnosis; Pancreatitis, Chronic - etiology; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Factors; Severity of Illness Index; Tomography, X-Ray Computed; treatment; Triglycerides - blood; Turkey; Young Adult; Turkey; treatment; hyperlipidemia; chronic pancreatitis
• ISSN: 1499-3872
• DOI: 10.1016/S1499-3872(14)60033-3

BACKGROUND: Hypertriglyceridemia induces acute recurrent pancreatitis, but its role in the etiology of chronic pancreatitis(CP) is controversial. This study aimed to evaluate the clinical laboratory and radiological findings of 7 patients with CP due to type 1 hyperlipidemia compared to CP patients with other or undefined etiological factors.METHODS: We retrospectively analyzed the clinical, laboratory and radiological findings of 7 CP patients with type 1 hyper lipidemia compared to CP patients without hypertriglyceridemia These 7 patients had multiple episodes of acute pancreatitis and had features of CP on abdominal CT, endoscopic retrograde cholangiopancreatography and/or endoscopic ultrasonography.RESULTS: All CP patients were classified into two groups: a group with type 1 hyperlipidemia (n=7) and a group with other etiologies (n=58). The mean triglyceride level was 2323±894mg/dL in the first group. Age at the diagnosis of CP in the first group was significantly younger than that in the second group(16.5±5.9 vs 48.3±13.5, P<0.001). The number of episodes of acute pancreatitis in the first group was significantly higher than that in the second group (15.0±6.8 vs 4.0±4.6, P=0.011)The number of splenic vein thrombosis in the first group was significantly higher than that in the second group (4/7 vs 9/58P=0.025). Logistic regression analysis found that younger age was an independent predictor of CP due to hypertriglyceridemia(r=0.418, P=0.000).CONCLUSIONS: Type 1 hyperlipidemia appears to be an etiological factor even for a minority of patients with CP. It manifests at a younger age, and the course of the disease might be severe.