Tissue-Type Plasminogen Activator: A Multifaceted Modulator of Neurotransmission and Synaptic Plasticity

For over a decade, tissue-type plasminogen activator (t-PA), a serine protease classically known for its profibrinolytic role in the vasculature, has been implicated in numerous aspects of the synaptic plasticity process. But despite being the most intensively studied protease of the CNS, the mechan...

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Bibliographic Details
Published inNeuron (Cambridge, Mass.) Vol. 50; no. 5; pp. 673 - 678
Main Authors Samson, Andre L., Medcalf, Robert L.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2006
Elsevier Limited
Subjects
Acquisitions & mergers
Animals
Ethanol
Mice
Neuronal Plasticity - physiology
Neurosciences
Neurotransmitter Agents - physiology
Participation
Permeability
Rodents
Synaptic Transmission - physiology
Tissue Plasminogen Activator - physiology
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Summary:For over a decade, tissue-type plasminogen activator (t-PA), a serine protease classically known for its profibrinolytic role in the vasculature, has been implicated in numerous aspects of the synaptic plasticity process. But despite being the most intensively studied protease of the CNS, the mechanisms and molecular mediators behind the action of t-PA on synaptic efficacy remain largely undefined. Rather than examine the role of t-PA in proteolytic remodeling of the synaptic extracellular matrix, this review will focus on the evidence that defines t-PA as a direct modulator of neurotransmission and synaptic plasticity by impacting on glutamatergic and dopaminergic pathways.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2006.04.013