Herbal Transformation by Fermentation

We herein show a dramatic change of herbal properties of the composition as well as function via fermentation of Cynanchi atrati Radix (family Asclepiadaceae). Cynanchi atrati Radix showed a high cytotoxicity against B16-F10 melanoma cell line, but the function of Cynanchi atrati Radix was completel...

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Published inJournal of acupuncture and meridian studies Vol. 13; no. 5; pp. 167 - 168
Main Authors Son, Chang-Gue, Lee, Sam-Keun, Choi, In-Kyu, Jang, Eun-Su, Bang, Kee-Jung
Format Journal Article
LanguageEnglish
Published Korea (South) Elsevier B.V 01.10.2020
Medical Association of Pharmacopuncture Institute
사단법인약침학회
Subjects
Biotransformation
Cell Line, Tumor
Chromatography, High Pressure Liquid
cynanchi atrati Radix
Cynanchum - chemistry
Cynanchum - metabolism
Cynanchum - microbiology
Drugs, Chinese Herbal - metabolism
Fermentation
herbal
Humans
lactobacillus
Lactobacillus - metabolism
한의학
lactobacillus
fermentation
herbal
cynanchi atrati Radix
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Summary:We herein show a dramatic change of herbal properties of the composition as well as function via fermentation of Cynanchi atrati Radix (family Asclepiadaceae). Cynanchi atrati Radix showed a high cytotoxicity against B16-F10 melanoma cell line, but the function of Cynanchi atrati Radix was completely changed into anti-melanin activity at very low concentration after Lactobacillus -fermentation. In addition, the compounds were drastically changed as shown in HPLC-based profile. Furthermore, this transformation has been achieved by only Lactobacillus -fermentation. This study proposes an strategy which we need to consider in the herb-derived material researches including pharmacopuncture.
Bibliography:https://www.sciencedirect.com/science/article/pii/S2005290120301382
ISSN:2005-2901
2093-8152
DOI:10.1016/j.jams.2020.10.001