Viral vectors for gene therapy: Current state and clinical perspectives

Gene therapy is the straightforward approach for the application of recent advances in molecular biology into clinical practice. One of the major obstacles in the development of gene therapy is the delivery of the effector to and into the target cell. Unfortunately, most methods commonly used in lab...

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Published inBiochemistry (Moscow) Vol. 81; no. 7; pp. 700 - 708
Main Authors Lukashev, A. N., Zamyatnin, A. A.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.07.2016
Springer
Springer Nature B.V
Subjects
Adenoviridae - genetics
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cell activation
Cell survival
Expression vectors
Gene therapy
Genetic Therapy
Genetic Vectors - genetics
Genetic Vectors - metabolism
Genetic Vectors - therapeutic use
Genomes
Humans
Lentivirus - genetics
Life Sciences
Microbiology
Molecular biology
Molecular modelling
Neoplasms - therapy
Retroviridae - genetics
Review
Survival
Vectors (Biology)
Viruses
Viruses - genetics
molecular targeting
viral vector
RNA
DNA
smart drugs
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Summary:Gene therapy is the straightforward approach for the application of recent advances in molecular biology into clinical practice. One of the major obstacles in the development of gene therapy is the delivery of the effector to and into the target cell. Unfortunately, most methods commonly used in laboratory practice are poorly suited for clinical use. Viral vectors are one of the most promising methods for gene therapy delivery. Millions of years of evolution of viruses have resulted in the development of various molecular mechanisms for entry into cells, long-term survival within cells, and activation, inhibition, or modification of the host defense mechanisms at all levels. The relatively simple organization of viruses, small genome size, and evolutionary plasticity allow modifying them to create effective instruments for gene therapy approaches. This review summarizes the latest trends in the development of gene therapy, in particular, various aspects and prospects of the development of clinical products based on viral delivery systems.
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ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297916070063