Development of newborn and infant vaccines

Vaccines for early-life immunization are a crucial biomedical intervention to reduce global morbidity and mortality, yet their developmental path has been largely ad hoc, empiric, and inconsistent. Immune responses of human newborns and infants are distinct and cannot be predicted from those of huma...

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Bibliographic Details
Published inScience translational medicine Vol. 3; no. 90; p. 90ps27
Main Authors Sanchez-Schmitz, Guzman, Levy, Ofer
Format Journal Article
LanguageEnglish
Published United States 06.07.2011
Subjects
Adult
Animals
Child, Preschool
Communicable Disease Control
Humans
Immune System - immunology
Infant, Newborn - immunology
Vaccination
Vaccines - immunology
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Summary:Vaccines for early-life immunization are a crucial biomedical intervention to reduce global morbidity and mortality, yet their developmental path has been largely ad hoc, empiric, and inconsistent. Immune responses of human newborns and infants are distinct and cannot be predicted from those of human adults or animal models. Therefore, understanding and modeling age-specific human immune responses will be vital to the rational design and development of safe and effective vaccines for newborns and infants.
ISSN:1946-6242
DOI:10.1126/scitranslmed.3001880