Outcome of Heart Failure with Preserved Ejection Fraction in a Population-Based Study

• Published in: The New England journal of medicine Vol. 355; no. 3; pp. 260 - 269
• Main Authors: Bhatia, R. Sacha, Tu, Jack V, Lee, Douglas S, Austin, Peter C, Fang, Jiming, Haouzi, Annick, Gong, Yanyan, Liu, Peter P
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 20.07.2006
• Subjects: Aged; Biological and medical sciences; Cardiology. Vascular system; Clinical outcomes; Cohort Studies; Female; General aspects; Heart; Heart failure; Heart Failure - mortality; Heart Failure - physiopathology; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Hospitalization; Humans; Male; Medical sciences; Multivariate Analysis; Patient Readmission - statistics & numerical data; Prognosis; Public health; Stroke Volume; Survival Analysis; Heart failure; Medicine; Prognosis; Heart disease; Cardiovascular disease; Evolution; Population; Public health; Ejection fraction
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa051530

Among 2802 patients hospitalized with heart failure, 31 percent had a preserved ejection fraction. These patients, as compared with those with reduced ejection fraction, were more likely to be older and female and to have a history of hypertension and atrial fibrillation. However, the presenting features, complications, readmission rates, and mortality rates were similar in the two groups. Among patients with heart failure, 31 percent had a preserved ejection fraction. These patients were more likely to be older and female and to have a history of hypertension and atrial fibrillation. Heart failure has classically been considered to be a clinical syndrome associated with cardiac dilatation and impaired cardiac contractility. 1 However, studies have found that increasing numbers of patients presenting with clinical heart failure have an ejection fraction of more than 50 percent. 1 – 3 This entity, which has been termed “heart failure with preserved ejection fraction,” is attributed to abnormalities of diastolic function, although the exact mechanism is debated. 4 , 5 Prior data suggest that patients who have heart failure with preserved ejection fraction tend to be older, to be female, and to have a history of hypertension. 1 , 3 , 6 , 7 The . . .