Marine-derived metabolites of S-adenosylmethionine as templates for new anti-infectives

S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homose...

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Published inMarine Drugs Vol. 7; no. 3; pp. 401 - 434
Main Authors Sufrin, Janice R, Finckbeiner, Steven, Oliver, Colin M
Format Journal Article Book Review
LanguageEnglish
Published Switzerland MDPI AG 26.08.2009
Molecular Diversity Preservation International
Subjects
adenosylmethionine
Animals
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Bacteria - metabolism
Biological Products - chemistry
Biological Products - pharmacology
Drug Design
ethylene
Marine Biology
polyamines
Quorum Sensing
radical SAM
Review
S-Adenosylmethionine - metabolism
Structure-Activity Relationship
quorum sensing
radical SAM
ethylene
polyamines
adenosylmethionine
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Summary:S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homoserine lactones. Marine organisms produce numerous AdoMet metabolites whose novel structures can be regarded as lead compounds for anti-infective drug design.
Bibliography:ObjectType-Article-2
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These authors contributed equally to this work.
ISSN:1660-3397
1660-3397
DOI:10.3390/md7030401