Epithelial-mesenchymal transition: An emerging target in tissue fibrosis

Epithelial-mesenchymal transition (EMT) is involved in a variety of tissue fibroses. Fibroblasts/myofibroblasts derived from epithelial cells contribute to the excessive accumulation of fibrous connective tissue in damaged tissue, which can lead to permanent scarring or organ malfunction. Therefore,...

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Published inExperimental biology and medicine (Maywood, N.J.) Vol. 241; no. 1; pp. 1 - 13
Main Authors Li, Meirong, Luan, Fuxin, Zhao, Yali, Hao, Haojie, Zhou, Yong, Han, Weidong, Fu, Xiaobing
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.01.2016
Subjects
Epithelial-Mesenchymal Transition
Fibrosis - pathology
Fibrosis - therapy
Humans
Minireview
Epithelial-mesenchymal transition
mesenchymal stem cell
anti-fibrosis
fibroblast
myofibroblast
TGF-β
dedifferentiation
tissue fibrosis
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Summary:Epithelial-mesenchymal transition (EMT) is involved in a variety of tissue fibroses. Fibroblasts/myofibroblasts derived from epithelial cells contribute to the excessive accumulation of fibrous connective tissue in damaged tissue, which can lead to permanent scarring or organ malfunction. Therefore, EMT-related fibrosis cannot be neglected. This review highlights the findings that demonstrate the EMT to be a direct contributor to the fibroblast/myofibroblast population in the development of tissue fibrosis and helps to elucidate EMT-related anti-fibrotic strategies, which may enable the development of therapeutic interventions to suppress EMT and potentially reverse organ fibrosis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1535-3702
1535-3699
DOI:10.1177/1535370215597194