The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis

• Published in: Virus research Vol. 228; pp. 1 - 6
• Main Authors: Tarokhian, Hanieh, Taghadosi, Mahdi, Rafatpanah, Hushang, Rajaei, Taraneh, Azarpazhooh, Mahmoud Reza, Valizadeh, Narges, Rezaee, S.A. Rahim
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.01.2017
• Subjects: Adult; Basic-Leucine Zipper Transcription Factors - genetics; Blood Cell Count; carrier state; Cross-Sectional Studies; disease course; erythrocyte count; Erythrocyte Indices; erythrocytes; Female; gene expression; Gene Expression Regulation, Viral; Genes, MHC Class I; Genes, pX; HAM/TSP; HBZ; hematocrit; Histocompatibility Testing; HLA; HTLV-I Infections - blood; HTLV-I Infections - genetics; HTLV-I Infections - virology; Human T-lymphotropic virus 1 - physiology; Humans; leukocyte count; Male; Middle Aged; monitoring; mononuclear leukocytes; Neopterin; Neopterin - blood; Paraparesis, Tropical Spastic - diagnosis; Paraparesis, Tropical Spastic - etiology; pathogenesis; patients; Primate T-lymphotropic virus 1; Proviral load; Proviruses - genetics; quantitative polymerase chain reaction; Retroviridae; Retroviridae Proteins - genetics; Symptom Assessment; Tax; Viral Load; virulence; Virulence Factors - genetics; HBZ; HAM/TSP; Tax; Neopterin; HLA; Proviral load

Previous studies have suggested debatable roles of Tax and HBZ gene expression in the pathogenesis of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In this study, HTLV-1 and host interactions in the manifestation of HAM/TSP were evaluated. A cross-sectional study was conducted...